The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 18, 2022
Filed:
Oct. 10, 2018
University of Pittsburgh—of the Commonwealth System of Higher Education, Pittsburgh, PA (US);
Yoram Vodovotz, Sewickley, PA (US);
Alexey Solovyev, Pittsburgh, PA (US);
David Okonkwo, Pittsburgh, PA (US);
Maxim Mikheev, Clairton, PA (US);
Qi Mi, Pittsburgh, PA (US);
Jorg Gerlach, Pittsburgh, PA (US);
Gregory M. Constantine, Baden, PA (US);
University of Pittsburgh—Of the Commonwealth System of Higher Education, Pittsburgh, PA (US);
Abstract
A bioreactor is provided which contains cells capable of producing cytokine inhibitors in response to cytokines, in a manner regulated by the local or systemic milieu of an individual patient and predicted by mechanistic computational simulations. The bioreactor transfers the cytokine inhibitors to a patient in need of control of the inflammation process as part of a disease or condition in the patient, such as sepsis, trauma, traumatic brain injury, or wound healing. Related methods also are provided.