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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11224652 B1

PDFFull Text
Date of Patent:
Jan. 18, 2022

Filed:

Aug. 04, 2017

Multivalent pneumococcal polysaccharide-protein conjugate composition

Applicants:

Sanofi Pasteur Inc., Swiftwater, PA (US);

SK Bioscience Co., Ltd., Seongnam-si, KR;

Inventors:

Kyungjun An, Seoul, KR;

Wooyoung Choi, Yongin-si, KR;

Dongsoo Ham, Suwon-si, KR;

Hun Kim, Suwon-si, KR;

Jinhwan Shin, Seoul, KR;

Robert Hopfer, Roaring Brook Township, PA (US);

Richard D. Kensinger, Henryville, PA (US);

Moe Kyaw, Swiftwater, PA (US);

Eric Desauziers, Lyons, FR;

Clotilde El Guerche Seblain, Lyons, FR;

Philippe Talaga, Lyons, FR;

Assignees:

SANOFI PASTEUR INC., Swiftwater, PA (US);

SK BIOSCIENCE CO., LTD., Seongnam-si, KR;

Attorney:

MH2 Technology Law Group, LLP

Primary Examiner:

Rodney P Swartz

Int. Cl.
CPC ...
A61K 39/00 (2006.01); A61K 39/02 (2006.01); A61K 39/09 (2006.01); A61K 39/385 (2006.01); A61K 47/64 (2017.01); A61P 31/04 (2006.01); A61K 39/39 (2006.01);
U.S. Cl.
CPC ...
A61K 39/385 (2013.01); A61K 39/092 (2013.01); A61K 39/39 (2013.01); A61K 47/646 (2017.08); A61K 47/6415 (2017.08); A61P 31/04 (2018.01); A61K 2039/54 (2013.01); A61K 2039/55505 (2013.01); A61K 2039/6037 (2013.01); A61K 2039/70 (2013.01);
Abstract

Provided are mixed carrier, multivalent pneumococcal conjugate compositions comprising 16 different pneumococcal capsular polysaccharide-protein conjugates, wherein each of the conjugates includes a capsular polysaccharide from a different serotype ofconjugated to either tetanus toxoid or CRM, wherein theserotypes are selected from 1, 3, 4, 5, 6A, 6B, 7F, 9V, 12F, 14, 18C, 19A, 19F, 22F, 23F, and 33F, wherein two of the capsular polysaccharides are conjugated to tetanus toxoid and the remaining capsular polysaccharides are conjugated to CRM, and wherein the two capsular polysaccharides that are conjugated to tetanus toxoid are selected from the group consisting of serotypes 1, 3, and 5. Also provided are methods of producing the mixed carrier, multivalent pneumococcal conjugate compositions and methods of using the same for prophylaxis againstinfection or disease in a subject.

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