The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 18, 2022

Filed:

Nov. 28, 2018
Applicant:

Berg Llc, Framingham, MA (US);

Inventors:

Niven Rajin Narain, Cambridge, MA (US);

Rangaprasad Sarangarajan, Boylston, MA (US);

Vivek K. Vishnudas, Bedford, MA (US);

Stephane Gesta, Arlington, MA (US);

Enxuan Jing, West Roxbury, MA (US);

Assignee:

Berg LLC, Framingham, MA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/51 (2006.01); A61K 49/00 (2006.01); A61K 38/00 (2006.01); A61K 9/00 (2006.01); C12N 9/88 (2006.01); C12Q 1/54 (2006.01); A61K 47/59 (2017.01); A61K 47/64 (2017.01);
U.S. Cl.
CPC ...
A61K 38/51 (2013.01); A61K 9/0019 (2013.01); A61K 9/0053 (2013.01); A61K 38/00 (2013.01); A61K 47/59 (2017.08); A61K 47/64 (2017.08); A61K 49/0008 (2013.01); C12N 9/88 (2013.01); C12Q 1/54 (2013.01); C12Y 402/01011 (2013.01); G01N 2333/988 (2013.01); G01N 2800/042 (2013.01);
Abstract

The invention provides compositions comprising Eno1 for delivery to a muscle. Further, the invention provides a method for normalizing blood glucose in a subject with elevated blood glucose, comprising administering to the subject enolase 1 (Eno1), thereby normalizing blood glucose in the subject. The invention also provides methods of treating one or more conditions including impaired glucose tolerance, insulin resistance, pre-diabetes, and diabetes, especially type 2 diabetes in a subject, comprising administering to the subject enolase 1 (Eno1), thereby treating the condition in the subject. In certain methods of the invention, the Eno1 is delivered to muscle.


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