The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 18, 2022

Filed:

Sep. 05, 2018
Applicant:

University of Kentucky Research Foundation, Lexington, KY (US);

Inventors:

Jurgen Rohr, Lexington, KY (US);

Oleg Tsodikov, Lexington, KY (US);

Markos Leggas, Lexington, KY (US);

Caixia Hou, Lexington, KY (US);

Joseph Eckenrode, Lexington, TN (US);

Prithiba Mitra, Lexington, KY (US);

Abhisek Mandal, Lexington, KY (US);

Assignee:
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/7056 (2006.01); A61P 35/02 (2006.01); A61K 31/704 (2006.01);
U.S. Cl.
CPC ...
A61K 31/7056 (2013.01); A61K 31/704 (2013.01); A61P 35/02 (2018.01);
Abstract

Mithramycin side chain carboxylic acid (MTM-SA) derivative are provided, which include a substituted amino acid derivative, a substituted amino acid dipeptide derivative, or an unsubstituted dipeptide derivative. The MTM-SA derivatives are useful for treatment of cancer or neuro-diseases associated with an aberrant erythroblast transformation-specific transcription factor. Unique MTM-SA derivatives have increased selectively toward ETS transcription factor.


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