The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 11, 2022
Filed:
Mar. 07, 2018
Nantcell, Inc., Culver City, CA (US);
Patrick Soon-Shiong, Culver City, CA (US);
Shahrooz Rabizadeh, Culver City, CA (US);
Kayvan Niazi, Culver City, CA (US);
Stephen Charles Benz, Culver City, CA (US);
Laurent H. Boissel, Culver City, CA (US);
Hans Klingemann, Culver City, CA (US);
Barry J. Simon, Culver City, CA (US);
NantCell, Inc., Culver City, CA (US);
Abstract
Detection of under-expression of selected genes in NK cells is used to confirm a hypoxic tumor microenvironment that is ordinarily suppressive with respect to ADCC and cytotoxic cell killing of NK cells. Most notably, while hypoxia is known to upregulate HIF-1α and genes under the control of HIF-1α, hypoxia in a tumor microenvironment led to under-expression of selected genes, including HIF-1α. Thus, gene expression analysis of certain genes on NK cells can be used to detect conditions in a tumor that would indicate use of haNK cells.