The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 11, 2022
Filed:
Jan. 22, 2021
Applicant:
Cartesian Therapeutics, Inc., Gaithersburg, MD (US);
Inventors:
Yi Zhang, Gaithersburg, MD (US);
C. Andrew Stewart, Frederick, MD (US);
Metin Kurtoglu, Bethesda, MD (US);
Murat V. Kalayoglu, Silver Spring, MD (US);
Michael S. Singer, Chestnut Hill, MA (US);
Assignee:
Cartesian Therapeutics, Inc., Gaithersburg, MD (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); C07K 16/30 (2006.01); C07K 14/705 (2006.01); A61K 39/395 (2006.01); C07K 14/715 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/70517 (2013.01); A61K 39/3955 (2013.01); A61K 39/39558 (2013.01); C07K 16/2878 (2013.01); C07K 16/2896 (2013.01); C07K 16/30 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/53 (2013.01); C07K 2317/565 (2013.01); C07K 2317/622 (2013.01); C07K 2317/73 (2013.01); C07K 2317/76 (2013.01); C07K 2319/03 (2013.01);
Abstract
Provided herein are chimeric antigen receptors (CARs), such as those specific for BCMA, that have improved properties, including increased CAR T cell binding to BCMA and improved CAR T cell killing of BCMA-expressing cancer cells. Use of the CARs in immune cells (e.g., T cells), compositions (e.g., CARs and nucleic acid constructs encoding the same), and methods are also contemplated.