The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 11, 2022
Filed:
Feb. 20, 2018
Applicant:
Prelude Therapeutics, Incorporated, Wilmington, DE (US);
Inventors:
Juan Luengo, Phoenixville, PA (US);
Raul A. Leal, Newark, DE (US);
Hong Lin, Exton, PA (US);
Rupa Shetty, Blue Bell, PA (US);
Krishna Vaddi, Chadds Ford, PA (US);
Assignee:
Prelude Therapeutics Incorporated, Wilmington, DE (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 19/23 (2006.01); C07H 19/16 (2006.01); A61P 35/00 (2006.01); C07D 473/34 (2006.01); C07D 487/04 (2006.01);
U.S. Cl.
CPC ...
C07H 19/23 (2013.01); A61P 35/00 (2018.01); C07D 473/34 (2013.01); C07D 487/04 (2013.01); C07H 19/16 (2013.01);
Abstract
The disclosure is directed to compounds of Formula I, Formula II, Formula III, Formula IV, Formula V, or Formula VI: Methods of their use in inhibiting a protein arginine methyltransferase 5 (PRMT5) enzyme and treating disease, as well as methods of their preparation are also described.