The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 11, 2022

Filed:

May. 21, 2019
Applicant:

The Regents of the University of California, Oakland, CA (US);

Inventors:

Peter Walter, San Francisco, CA (US);

Carmela Sidrauski, Saratoga, CA (US);

Diego Acosta Alvear, San Francisco, CA (US);

Michelle R. Arkin, San Francisco, CA (US);

Christopher G. Wilson, Berkeley, CA (US);

Kean Hooi Ang, San Francisco, CA (US);

Brian R. Hearn, Lafayette, CA (US);

Punitha Vedantham, Burlingame, CA (US);

Adam R. Renslo, Oakland, CA (US);

Mervyn Maze, San Francisco, CA (US);

Susana Vacas, San Francisco, CA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 235/14 (2006.01); C07F 7/08 (2006.01); A61K 31/4192 (2006.01); C07D 403/12 (2006.01); C07D 495/04 (2006.01); C07C 255/54 (2006.01); C07C 257/14 (2006.01); C07C 271/24 (2006.01); C07C 271/52 (2006.01); C07C 211/29 (2006.01); C07C 317/22 (2006.01); C07C 317/44 (2006.01); C07C 323/60 (2006.01); C07C 235/20 (2006.01); C07C 235/22 (2006.01); C07C 235/24 (2006.01); A61K 31/165 (2006.01);
U.S. Cl.
CPC ...
C07C 235/14 (2013.01); A61K 31/165 (2013.01); A61K 31/4192 (2013.01); C07C 211/29 (2013.01); C07C 235/20 (2013.01); C07C 235/22 (2013.01); C07C 235/24 (2013.01); C07C 255/54 (2013.01); C07C 257/14 (2013.01); C07C 271/24 (2013.01); C07C 271/52 (2013.01); C07C 317/22 (2013.01); C07C 317/44 (2013.01); C07C 323/60 (2013.01); C07D 403/12 (2013.01); C07D 495/04 (2013.01); C07F 7/081 (2013.01); C07C 2601/04 (2017.05); C07C 2601/14 (2017.05);
Abstract

Provided herein, inter alia, are compounds and methods useful for modulating the translational effects of eIF2α phosphorylation, the Integrated Stress Response (ISR), and the unfolded protein response (UPR); for treating diseases; for increasing protein production, and for improving long-term memory.


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