The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 11, 2022

Filed:

Feb. 20, 2018
Applicants:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

John E. Macnair, Lansdale, PA (US);

Michael A. Winters, Doylestown, PA (US);

Thomas Svab, Plains, PA (US);

Sheng-ching Wang, Eagleville, PA (US);

William J. Smith, Harleysville, PA (US);

Cecilia Giovarelli, Allentown, PA (US);

Inventors:

John E. MacNair, Lansdale, PA (US);

Michael A. Winters, Doylestown, PA (US);

Thomas Svab, Plains, PA (US);

Sheng-Ching Wang, Eagleville, PA (US);

William J. Smith, Harleysville, PA (US);

Cecilia Giovarelli, Allentown, PA (US);

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/09 (2006.01); A61K 47/64 (2017.01); C07K 14/34 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/092 (2013.01); A61K 47/646 (2017.08); A61K 47/6415 (2017.08); C07K 14/34 (2013.01); A61K 38/00 (2013.01); A61K 2039/6037 (2013.01);
Abstract

The present invention provides immunogenic compositions having one or more polysaccharide-protein conjugates in which polysaccharides obtained from bacterial capsules are conjugated to diphtheria toxin fragment B (DTFB) or a variant thereof. The immunogenic compositions may be multivalent pneumococcal polysaccharide conjugate compositions in which polysaccharides from one or moreserotypes are conjugated to diphtheria toxin fragment B (DTFB) and, optionally, additional polysaccharides from one or more differentserotypes are conjugated to one or more other carrier proteins.


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