The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 11, 2022
Filed:
May. 17, 2016
Applicant:
The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center, Tel-Aviv, IL;
Inventors:
Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); A61K 38/16 (2006.01); C12N 15/07 (2006.01); A61P 35/00 (2006.01); A61K 31/713 (2006.01); A61K 45/06 (2006.01); C12N 15/86 (2006.01); C12N 15/63 (2006.01); C12N 15/09 (2006.01); A61K 35/761 (2015.01);
U.S. Cl.
CPC ...
A61K 31/713 (2013.01); A61K 35/761 (2013.01); A61K 45/06 (2013.01); A61K 48/005 (2013.01); A61K 48/0008 (2013.01); A61P 35/00 (2018.01); C12N 15/09 (2013.01); C12N 15/63 (2013.01); C12N 15/86 (2013.01); A61K 2300/00 (2013.01); C12N 2710/10343 (2013.01); C12N 2750/14143 (2013.01); C12N 2830/002 (2013.01); C12N 2830/15 (2013.01); C12N 2840/206 (2013.01);
Abstract
Provided are nucleic acid constructs and systems which comprise (i) a first nucleic acid construct encoding a toxin operatively linked to a first promoter and at least one cancer-associated signaling responsive enhancer element; and (ii) a second nucleic acid construct encoding an anti-toxin operatively linked to a second promoter, the second promoter being stronger than the first promoter. Also provided are pharmaceutical compositions comprising same and methods of using same for treating cancer.