The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 11, 2022
Filed:
Jan. 21, 2016
Applicant:
Genevant Sciences Gmbh, Basel, CH;
Inventors:
Mary G. Prieve, Lake Forest Park, WA (US);
Michael E. Houston, Jr., Kirkland, WA (US);
Pierrot Harvie, Seattle, WA (US);
Sean D. Monahan, Lake Forest Park, WA (US);
Assignee:
Genevant Sciences GmbH, Basel, CH;
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/7105 (2006.01); A61K 9/00 (2006.01); A61K 47/18 (2017.01); A61K 47/32 (2006.01); A61K 9/127 (2006.01); A61K 9/51 (2006.01); C08F 293/00 (2006.01); A61K 48/00 (2006.01); A61K 31/407 (2006.01); A61K 31/5365 (2006.01); A61K 31/704 (2006.01); A61K 31/7048 (2006.01); A61K 31/4745 (2006.01); A61K 31/47 (2006.01); A61K 31/475 (2006.01); A61K 31/40 (2006.01); A61K 9/107 (2006.01);
U.S. Cl.
CPC ...
A61K 31/7105 (2013.01); A61K 9/0019 (2013.01); A61K 9/1075 (2013.01); A61K 9/1272 (2013.01); A61K 9/5123 (2013.01); A61K 31/40 (2013.01); A61K 31/407 (2013.01); A61K 31/47 (2013.01); A61K 31/475 (2013.01); A61K 31/4745 (2013.01); A61K 31/5365 (2013.01); A61K 31/704 (2013.01); A61K 31/7048 (2013.01); A61K 47/186 (2013.01); A61K 47/32 (2013.01); A61K 48/0041 (2013.01); C08F 293/00 (2013.01);
Abstract
Disclosed are methods for delivering a therapeutic or diagnostic agent to the cytosol of a cell in a subject. The disclosed methods generally include administering to the subject an effective amount of a lipid nanoparticle comprising the therapeutic or diagnostic agent and an effective amount of a membrane-destabilizing polymer. Also disclosed are related compositions and delivery systems.