The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 11, 2022
Filed:
Jun. 15, 2015
Applicant:
The Children's Hospital of Philadelphia, Philadelphia, PA (US);
Inventors:
Hakon Hakonarson, Malvern, PA (US);
Tara Wenger, Seattle, WA (US);
Charlly Kao, Philadelphia, PA (US);
Dexter Hadley, Philadelphia, PA (US);
Zhi-liang Wu, North Potomac, MD (US);
Joseph Glessner, Mullica Hill, NJ (US);
Assignee:
THE CHILDREN'S HOSPITAL OF PHILADELPHIA, Philadelphia, PA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2018.01); C12P 19/34 (2006.01); A61K 31/454 (2006.01); G16B 20/00 (2019.01); C12Q 1/6883 (2018.01);
U.S. Cl.
CPC ...
A61K 31/454 (2013.01); C12Q 1/6883 (2013.01); G16B 20/00 (2019.02); C12Q 2600/118 (2013.01); C12Q 2600/156 (2013.01);
Abstract
Methods for diagnosing and treating autism spectral disorders are encompassed. In one embodiment, a patient is diagnosed as having autism spectral disorder if at least one CNV in an mGluR network gene is found in a patient sample. Patients with at least one mGluR network gene CNV are effectively treated with (+)-5-oxo-Dprolinepiperidinamide monohydrate (NS-105).