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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11219195 B1

PDFFull Text
Date of Patent:
Jan. 11, 2022

Filed:

Jan. 10, 2019

Genetically modified major histocompatibility complex mice

Applicant:

Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);

Inventors:

Lynn Macdonald, Harrison, NY (US);

Andrew J. Murphy, Croton-on-Hudson, NY (US);

Naxin Tu, Pleasantville, NY (US);

Cagan Gurer, Chappaqua, NY (US);

Vera Voronina, North Bethesda, MD (US);

Sean Stevens, Del Mar, CA (US);

Assignee:

Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);

Attorneys:

FisherBroyles, LLP

Rita S. Wu

Margarita Zippin

Primary Examiner:

Shin Lin Chen

Int. Cl.
CPC ...
A01N 63/00 (2020.01); C12N 15/63 (2006.01); C12N 15/00 (2006.01); C07H 21/04 (2006.01); A01K 67/027 (2006.01); C07K 14/74 (2006.01); C12N 15/85 (2006.01);
U.S. Cl.
CPC ...
A01K 67/0278 (2013.01); A01K 67/0271 (2013.01); C07K 14/70539 (2013.01); A01K 2217/072 (2013.01); A01K 2217/075 (2013.01); A01K 2227/105 (2013.01); A01K 2267/03 (2013.01); C07H 21/04 (2013.01); C12N 15/8509 (2013.01);
Abstract

The invention provides genetically modified non-human animals that express a humanized MHC II protein (humanized MHC II α and β polypeptides), as well as embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified animals and methods of making the same. Methods of using the genetically modified animals to study various aspects of human immune system are provided.

Find Patent Forward Citations

Macdonald, Lynn. (2022). Genetically modified major histocompatibility complex mice (U.S. Patent No. 11219195). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11219195

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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