The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 04, 2022
Filed:
Sep. 05, 2017
Applicant:
Ikaria Inc., Cambridge, MA (US);
Inventor:
Stephen DiMagno, Chicago, IL (US);
Assignee:
Ikaria Inc., Cambridge, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12P 21/02 (2006.01); C07C 327/44 (2006.01); C07C 233/51 (2006.01); C07K 14/545 (2006.01); C07B 59/00 (2006.01); C07C 327/42 (2006.01); C07K 14/54 (2006.01); C12N 9/00 (2006.01);
U.S. Cl.
CPC ...
C12P 21/02 (2013.01); C07B 59/001 (2013.01); C07B 59/008 (2013.01); C07C 233/51 (2013.01); C07C 327/42 (2013.01); C07C 327/44 (2013.01); C07K 14/54 (2013.01); C07K 14/545 (2013.01); C12N 9/93 (2013.01); C12Y 601/01026 (2013.01); C07B 2200/05 (2013.01);
Abstract
Provided herein are compositions and methods for generating polypeptides using non-natural amino acids (nnAAs) and genetic machinery, wherein the modified polypeptides, such as therapeutic polypeptides, bind to albumin, such as serum albumin. Methods of substituting a non-natural amino acid in a first polypeptide to obtain a modified polypeptide, the nnAA in some instances comprising an albumin targeting group, are disclosed, as are methods for making populations of such modified polypeptides. A therapeutic polypeptide, interleukin-1 receptor antagonist (IL-1RA) is exemplified using the disclosed methods.