The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 04, 2022
Filed:
May. 02, 2016
Applicants:
Andrew Man Chung Wo, Edgartown, MA (US);
National Taiwan University, Taipei, TW;
Academia Sinica, Taipei, TW;
Inventors:
Assignees:
Primary Examiner:
Int. Cl.
CPC ...
C07K 5/00 (2006.01); C12N 9/12 (2006.01); A61K 45/06 (2006.01); C07K 14/00 (2006.01); A61K 39/395 (2006.01); C07K 14/71 (2006.01); A61K 31/517 (2006.01); A61K 38/17 (2006.01); A61K 31/5377 (2006.01); A61P 35/00 (2006.01); A61K 38/45 (2006.01);
U.S. Cl.
CPC ...
C12N 9/12 (2013.01); A61K 31/517 (2013.01); A61K 31/5377 (2013.01); A61K 38/179 (2013.01); A61K 38/45 (2013.01); A61K 39/395 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); C07K 14/00 (2013.01); C07K 14/71 (2013.01); C12Y 207/11001 (2013.01); C07K 2319/10 (2013.01); C07K 2319/41 (2013.01); C07K 2319/43 (2013.01);
Abstract
The present disclosure includes a PINK1-C-terminal domain (PINK1-CTD) polypeptide that binds to ERBB tyrosine kinase domain (ERBB-TKD) and therefore impedes ERBB from dimerization and activation. The PINK1-CTD polypeptide inhibits, prevents and/or treats ERBB-expressing cancers. The disclosure demonstrates the anti-tumor function of the PINK1-CTD, which provides a new direction for ERBB-expressing cancer therapy.