The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 04, 2022
Filed:
Oct. 29, 2019
Intarcia Therapeutics Inc., Boston, MA (US);
William Blackwell, Research Triangle Park, NC (US);
Ved P. Srivastava, Research Triangle Park, NC (US);
Mark A. Paulik, Research Triangle Park, NC (US);
Andrew Young, Research Triangle Park, NC (US);
Robert Neil Hunter, III, Boston, MA (US);
Steven Thomas Dock, Boston, MA (US);
Intarcia Therapeutics Inc., Boston, MA (US);
Abstract
This invention relates to isolated polypeptides that are glucagon-receptor selective analogs and peptide derivatives thereof. These analogs are selective for human glucagon receptor with improved solubility, thermal stability, and physicochemical properties as compared to native endogenous glucagon. This invention also relates to methods of using such polypeptides in a variety of therapeutic and diagnostic indications, as well as methods of producing such polypeptides. These analogs are useful, alone or in combination with other therapeutic peptides, in methods of treating obesity, diabetes, metabolic disorders, and other disorders or disease.