The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 04, 2022
Filed:
Aug. 16, 2018
Southern University of Science and Technology, Shenzhen, CN;
Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences, Shenzhen, CN;
Keith Man Chung Wong, Shenzhen, CN;
Chuangjun Liu, Shenzhen, CN;
Ping Gong, Shenzhen, CN;
Lihua Zhou, Shenzhen, CN;
Lintao Cai, Shenzhen, CN;
SOUTHERN UNIVERSITY OF SCIENCE AND TECHNOLOGY, Shenzhen, CN;
SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY CHINESE ACADEMY OF SCIENCES, Shenzhen, CN;
Abstract
Through the use of a rhodamine appended chelate, a versatile strategy has been demonstrated to generate mitochondria-targeting photosensitizers via the incorporation of variety of luminescent transition metal systems. The generation of triplet excited state of rhodamine moiety endows the complexes with mitochondria-targeting photosensitizing ability to form singlet oxygen (O) for use as photodynamic therapy (PDT) agent. The combination of rhodamine organic dye and luminescent transition metal centers in such hybrid systems exhibits the synergistic merits, including low dark cytotoxicity, selective tumor cell uptake, high molar absorptivity for low-energy excitation in the visible region, and high photostability.