The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 04, 2022

Filed:

Jan. 24, 2018
Applicant:

Ancureall Pharmaceutical (Shanghai) Co., Ltd., Shanghai, CN;

Inventors:

Jutong Si, Shanghai, CN;

Guan Wang, Shanghai, CN;

Meifeng Jiang, Shanghai, CN;

Zhihe Yang, Shanghai, CN;

Chentao Zhou, Shanghai, CN;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/14 (2006.01); A61P 35/00 (2006.01); C07D 213/64 (2006.01); C07D 401/12 (2006.01); C07D 413/14 (2006.01); C07D 491/107 (2006.01);
U.S. Cl.
CPC ...
C07D 401/14 (2013.01); A61P 35/00 (2018.01); C07D 213/64 (2013.01); C07D 401/12 (2013.01); C07D 413/14 (2013.01); C07D 491/107 (2013.01);
Abstract

The invention relates to a histone methyltransferase EZH2 inhibitor, a preparation method and pharmaceutical use thereof. In particular, the invention relates to a compound represented by the general formula (I), a preparation method thereof, a pharmaceutical composition containing the same, and a use thereof as a histone methyltransferase EZH2 inhibitor for treating diseases associated with the histone methyltransferase EZH2, especially cancer. The definition of each substituents in the general formula (I) is same as the definition in the specification.


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