IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11214548 B1

PDFFull Text
Date of Patent:
Jan. 04, 2022

Filed:

Sep. 24, 2019

Cannabinoid receptor modulators

Applicant:

Arena Pharmaceuticals, Inc., San Diego, CA (US);

Inventors:

Robert M. Jones, San Diego, CA (US);

Sangdon Han, San Diego, CA (US);

Lars Thoresen, San Diego, CA (US);

Jae-Kyu Jung, San Diego, CA (US);

Sonja Strah-Pleynet, Newton, MA (US);

Xiuwen Zhu, San Diego, CA (US);

Yifeng Xiong, San Diego, CA (US);

Dawei Yue, San Diego, CA (US);

Assignee:

Arena Pharmaceuticals, Inc., San Diego, CA (US);

Attorney:

Fish & Richardson P.C.

Primary Examiner:

Kortney L Klinkel

Assistant Examiner:

William Y Lee

Int. Cl.
CPC ...
C07D 231/24 (2006.01); C07D 401/04 (2006.01); C07D 401/14 (2006.01); C07D 403/04 (2006.01); C07D 405/14 (2006.01); C07F 9/6558 (2006.01); C07D 401/12 (2006.01); C07D 403/12 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01); C07D 231/54 (2006.01);
U.S. Cl.
CPC ...
C07D 231/54 (2013.01); C07D 401/04 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 403/12 (2013.01); C07D 405/14 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07F 9/65583 (2013.01);
Abstract

The present invention relates to certain compounds of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the cannabinoid CB2 receptor. The present invention further relates to certain compounds of Formula Ia and pharmaceutical compositions thereof that modulate the activities of both the CB1 receptor and the CB2 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of: pain, for example bone and joint pain, muscle pain, dental pain, migraine and other headache pain, inflammatory pain, neuropathic pain, pain that occurs as an adverse effect of therapeutics and pain associated with osteoarthritis; hyperalgesia; allodynia; inflammatory hyperalgesia; neuropathic hyperalgesia; acute nociception; osteoporosis; multiple sclerosis-associated spasticity; autoimmune disorders; allergic reactions; CNS inflammation; atherosclerosis; undesired immune cell activity and inflammation; age-related macular degeneration; cough; leukemia; lymphoma; CNS tumors; prostate cancer; Alzheimer's disease; stroke-induced damage; dementia; amyotrophic lateral sclerosis, and Parkinson's disease.

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