The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 04, 2022
Filed:
Nov. 16, 2015
Applicant:
Neurovision Pharma Gmbh, Grünwald, DE;
Inventors:
Assignee:
NEUROVISION PHARMA GMBH, Grünwald, DE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/113 (2010.01); A61K 9/00 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); A61K 31/7125 (2006.01);
U.S. Cl.
CPC ...
A61K 31/7125 (2013.01); C12N 15/1136 (2013.01); C12N 15/1138 (2013.01); A61K 9/0019 (2013.01); A61K 9/0085 (2013.01); C12N 2310/11 (2013.01); C12N 2310/313 (2013.01); C12N 2310/315 (2013.01); C12N 2310/3231 (2013.01); C12N 2310/341 (2013.01); C12N 2310/346 (2013.01); C12N 2320/30 (2013.01); C12Y 207/1103 (2013.01);
Abstract
The present invention relates to antisense-oligonucleotides having a length of at least 10 nucleotides, wherein at least two of the nucleotides are LNAs, their use as inhibitors of TGF-R signaling, pharmaceutical compositions containing such antisense-oligonucleotides and the use for prophylaxis and treatment of neurological, neurodegenerative, fibrotic and hyperproliferative diseases.