The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 04, 2022

Filed:

Jun. 17, 2019
Applicant:

HK Pharma, San Clemente, CA (US);

Inventor:

Jeffrey Alan Klein, San Juan Capistrano, CA (US);

Assignee:

HK Pharma, San Clemente, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/00 (2006.01); A61K 45/06 (2006.01); A61K 31/137 (2006.01); A61K 31/167 (2006.01); A61M 5/14 (2006.01); A61K 31/546 (2006.01); A61M 25/00 (2006.01);
U.S. Cl.
CPC ...
A61K 9/0021 (2013.01); A61K 9/0019 (2013.01); A61K 31/137 (2013.01); A61K 31/167 (2013.01); A61K 31/546 (2013.01); A61K 45/06 (2013.01); A61M 5/14 (2013.01); A61M 25/007 (2013.01);
Abstract

A method of subcutaneous delivery of a drug or a therapeutic agent to a subject to treat a localized condition, the method including obtaining a liquid composition including the drug or the therapeutic agent dissolved in a tumescent solution, wherein the tumescent solution includes the drug or the therapeutic agent a vasoconstrictor; and a pharmaceutically acceptable carrier; and delivering a mass of the liquid composition subcutaneously to a localized tissue in the subject, wherein the drug or the therapeutic agent treats the localized condition in the localized tissue, wherein a concentration of the drug or the therapeutic agent subcutaneously delivered exceeds a concentration of the drug or the therapeutic agent that can be safely achieved by intravenous delivery, and wherein an amount of the drug or the therapeutic agent located at an outer boundary of the mass of fluid and available for absorption is less than an amount of the drug or the therapeutic agent located within a central portion of the mass of fluid and virtually isolated from the systemic circulation by virtue of capillary vasoconstriction.


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