The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 28, 2021
Filed:
Dec. 19, 2013
Ventana Medical Systems, Inc., Tucson, AZ (US);
The Cleveland Clinic Foundation, Cleveland, OH (US);
The University of Melbourne, Victoria, AU;
Srinivas Chukka, San Jose, CA (US);
Olcay Sertel, Sunnyvale, CA (US);
Anindya Sarkar, Milpitas, CA (US);
Nikolaus Wick, Innsbruck, AT;
Shalini Singh, Tucson, AZ (US);
Crystal Schemp, Tucson, AZ (US);
Paul Waring, Melbourne, AU;
Raymond Tubbs, Cleveland, OH (US);
VENTANA MEDICAL SYSTEMS, INC., Tuscon, AZ (US);
THE CLEVELAND CLINIC FOUNDATION, Cleveland, OH (US);
THE UNIVERSITY OF MELBOURNE, Victoria, AU;
Abstract
Heterogeneity for biomarkers in a tissue sample can be calculated. A heterogeneity score can be combined with an immunohistochemistry combination score to provide breast cancer recurrence prognosis. Heterogeneity can be based on percent positivity determinations for a plurality of biomarkers according to how many cells in the sample stain positive. An immunohistochemistry combination score can be calculated. An imaging tool can support a digital pathologist workflow that includes designating fields of view in an image of the tissue sample. Based on the fields of view, a heterogeneity metric can be calculated and combined with an immunohistochemistry combination score to generate a breast cancer recurrence prognosis score.