The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 28, 2021
Filed:
Sep. 30, 2016
Applicant:
Regents of the University of Minnesota, Minneapolis, MN (US);
Inventor:
Daniel Attilio Vallera, Richfield, MN (US);
Assignee:
Regents of the University of Minnesota, Minneapolis, MN (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/68 (2017.01); C07K 14/34 (2006.01); A61K 38/00 (2006.01); C12N 9/10 (2006.01); C07K 14/54 (2006.01); C07K 14/485 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
C12N 9/1077 (2013.01); A61K 47/6829 (2017.08); A61P 35/00 (2018.01); C07K 14/34 (2013.01); C07K 14/485 (2013.01); C07K 14/5437 (2013.01); C12Y 204/02036 (2013.01); A61K 38/00 (2013.01); C07K 2319/01 (2013.01); C07K 2319/33 (2013.01); C07K 2319/55 (2013.01); C07K 2319/74 (2013.01);
Abstract
This disclosure provides a bispecific ligand directed toxin (BLT) that includes a diphtheria toxin (DT) molecule that has been mutated to create a DT molecule that induces less of an immune response than native diphtheria toxin. The deimmunized DT molecule is fused with targeting ligands to create a fusion protein that can selectively deliver the deimmunized DT to target cells to kill the target cells.