The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 28, 2021
Filed:
Apr. 27, 2018
Sentinel Oncology Limited, Cambridge, GB;
Robert George Boyle, Cambridge, GB;
David Winter Walker, Linton, GB;
Richard Justin Boyce, Newmarket, GB;
SENTINEL ONCOLOGY LIMITED, Cambridge, GB;
Abstract
The invention provides compounds of the formula (3): or a pharmaceutically acceptable salt or tautomer thereof, wherein:Z is a 5-membered heteroaryl ring containing one or two nitrogen ring members and optionally one further heteroatom ring member selected from N and O;ring X is a benzene or pyridine ring;ring Y is a benzene, pyridine, thiophene or furan ring;Aris an optionally substituted benzene, pyridine, thiophene or furan ring;m is 0, 1 or 2;n is 0, 1 or 2;Ris selected from various substituents:Ris selected from hydrogen and a Chydrocarbon group;Ris selected from hydrogen and a Chydrocarbon group;Ris selected from various substituents;Ris selected from various substituents;Aris an optionally substituted phenyl, pyridyl or pyridone group;Ris a group Q-R—R;Qis absent or is a Csaturated hydrocarbon linker;Ris selected from O; C(O); C(O)O; CONR; N(R)CO; N(R)CONR, NR; and SONR;Ris selected from hydrogen and various substituents;and Ris selected from R. The compounds are useful in the treatment of cancers.