The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 28, 2021

Filed:

Sep. 18, 2019
Applicant:

Daiichi Sankyo Company, Limited, Tokyo, JP;

Inventors:

Noriyasu Haginoya, Tokyo, JP;

Takashi Suzuki, Tokyo, JP;

Miho Hayakawa, Tokyo, JP;

Masahiro Ota, Tokyo, JP;

Tomoharu Tsukada, Tokyo, JP;

Katsuhiro Kobayashi, Tokyo, JP;

Yosuke Ando, Tokyo, JP;

Takeshi Jimbo, Tokyo, JP;

Koichi Nakamura, Tokyo, JP;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4433 (2006.01); C07D 409/14 (2006.01); C07D 405/14 (2006.01); A61K 31/496 (2006.01); A61K 31/497 (2006.01); A61K 31/444 (2006.01); A61K 31/506 (2006.01); A61K 31/5377 (2006.01); A61K 31/501 (2006.01); C07B 59/00 (2006.01); C07C 309/04 (2006.01); C07C 309/35 (2006.01);
U.S. Cl.
CPC ...
C07D 409/14 (2013.01); A61K 31/444 (2013.01); A61K 31/496 (2013.01); A61K 31/497 (2013.01); A61K 31/501 (2013.01); A61K 31/506 (2013.01); A61K 31/5377 (2013.01); C07B 59/002 (2013.01); C07C 309/04 (2013.01); C07C 309/35 (2013.01); C07D 405/14 (2013.01); C07B 2200/05 (2013.01); C07B 2200/13 (2013.01);
Abstract

The present disclosure provides novel compounds or salts thereof, or crystals of the compounds or the salts, which inhibit Axl and are useful in the treatment of a disease caused by hyperfunction of Axl, the treatment of a disease associated with hyperfunction of Axl, and/or the treatment of a disease involving hyperfunction of Axl. The present disclosure provides pyridone derivatives having a tetrahydropyranylmethyl group represented by the following formula (I) having various substituents, or salts thereof, or crystals of the compounds or the salts, wherein R, R, R, R, R, W, X, Y, and Z are each as defined in the specification:


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