The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 28, 2021
Filed:
Apr. 12, 2018
Sichuan Kelun-biotech Biopharmaceutical Co., Ltd., Chengdu, CN;
Jiaqiang Cai, Chengdu, CN;
Tongtong Xue, Chengdu, CN;
Shuai Song, Chengdu, CN;
Jing Wang, Chengdu, CN;
Qiang Tian, Chengdu, CN;
Liang Xiao, Chengdu, CN;
Hanwen Deng, Chengdu, CN;
Liping Liu, Chengdu, CN;
Zujian Tang, Chengdu, CN;
Hong Zeng, Chengdu, CN;
Rongrong Long, Chengdu, CN;
Hongmei Song, Chengdu, CN;
Qiang Zhang, Chengdu, CN;
Guoqing Zhong, Chengdu, CN;
Dengnian Liu, Chengdu, CN;
Haitao Huang, Chengdu, CN;
Ruibin Hu, Chengdu, CN;
Lichun Wang, Chengdu, CN;
Jingyi Wang, Chengdu, CN;
SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD., Chengdu, CN;
Abstract
Provided is a method for modifying a chimeric antigen receptor-modified T cell (CAR-T cell). The method comprises expressing an SCFV-CDS TM-4-1BB-CD3ζ molecule in a T cell. The CAR-T cell prepared using the method can specifically recognize and bind to a tumor cell with elevated expression of a ROBO1 protein, and can be used to prevent and treat a corresponding tumor-related disease.