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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11207410 B1

PDFFull Text
Date of Patent:
Dec. 28, 2021

Filed:

Jul. 21, 2016

Systems and methods for treatments of an eye with a photosensitizer

Applicant:

Avedro, Inc., Waltham, MA (US);

Inventors:

Pavel Kamaev, Lexington, MA (US);

Marc D. Friedman, Needham, MA (US);

Assignee:

Avedro, Inc., Waltham, MA (US);

Attorney:

McDonnell Boehnen Hulbert & Berghoff LLP

Primary Examiner:

My-Chau T Tran

Int. Cl.
CPC ...
A61K 41/00 (2020.01); A61F 9/007 (2006.01); A61K 33/26 (2006.01); A61K 31/525 (2006.01); A61K 33/00 (2006.01); A61N 5/06 (2006.01); A61P 43/00 (2006.01); A61P 27/02 (2006.01); A61F 9/00 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
A61K 41/0057 (2013.01); A61F 9/0017 (2013.01); A61F 9/0079 (2013.01); A61K 9/0048 (2013.01); A61K 31/525 (2013.01); A61K 33/00 (2013.01); A61K 33/26 (2013.01); A61N 5/062 (2013.01); A61P 27/02 (2018.01); A61P 43/00 (2018.01); A61N 2005/0661 (2013.01);
Abstract

A formulation for an eye treatment includes a photosensitizer and a permeability enhancing composition. The permeability enhancing composition includes one or more permeability enhancers. The permeability enhancing composition has a hydrophilic and lipophilic balance increases a permeability of an area of the eye for the photosensitizer. The hydrophilic and lipophilic balance can be characterized by a Hydrophile-Lipophile Balance (HLB) number. For example, the area of the eye may include a corneal epithelium, the photosensitizer may include riboflavin, and the permeability enhancing composition may have a corresponding HLB number between approximately 12.6 and approximately 14.6.

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