The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 28, 2021

Filed:

Mar. 09, 2016
Applicants:

Avita International Ltd., Tortola, VG;

Fundação Butantan, São Paulo, BR;

Inventors:

Irina Kerkis, Sao Paulo, BR;

Alexandre Kerkis, Sao Paulo, BR;

Assignees:

AVITA INTERNATIONAL LTD., Tortola, VG;

FUNDAÇÃO BUTANTAN, Sao Paulo, BR;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/28 (2015.01); A61K 9/00 (2006.01); C12N 5/0775 (2010.01); A61K 35/30 (2015.01); C12N 5/0793 (2010.01); C12N 5/0797 (2010.01); C12N 5/071 (2010.01); A61K 35/32 (2015.01); C12N 5/079 (2010.01);
U.S. Cl.
CPC ...
A61K 35/28 (2013.01); A61K 9/0019 (2013.01); A61K 35/30 (2013.01); A61K 35/32 (2013.01); C12N 5/0619 (2013.01); C12N 5/0621 (2013.01); C12N 5/0623 (2013.01); C12N 5/0664 (2013.01); C12N 5/0678 (2013.01); C12N 2500/25 (2013.01); C12N 2500/38 (2013.01); C12N 2500/84 (2013.01); C12N 2500/90 (2013.01); C12N 2501/385 (2013.01); C12N 2501/39 (2013.01); C12N 2501/392 (2013.01); C12N 2501/395 (2013.01); C12N 2506/1361 (2013.01); C12N 2533/76 (2013.01);
Abstract

The invention provides pharmaceutical compositions comprising human immature dental pulp stem cells (hIDPSCs) wherein the hIDPSCs express CD44 and CD13. The invention also provides methods of treating a neurological disease or condition comprising systemically administering to a subject a pharmaceutical composition comprising hIDPSCs wherein the hIDPSCs express CD44 and CD13. For example, for treating neurological diseases or conditions including supporting the neuro-protective mechanism in subjects diagnosed with early HD or repairing lost DA neurons in subjects diagnosed with PD.


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