The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 28, 2021
Filed:
Feb. 27, 2018
Sloan Kettering Institute for Cancer Research, New York, NY (US);
Board of Regents, the University of Texas System, Austin, TX (US);
Jimmy Andrew Rotolo, Port Washington, NY (US);
Richard N. Kolesnick, New York, NY (US);
Renata Pasqualini, Los Ranchos de Albuquerque, NM (US);
Wadih Arap, Los Ranchos de Albuquerque, NM (US);
SLOAN KETTERING INSTITUTE FOR CANCER RESEARCH, New York, NY (US);
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, Austin, TX (US);
Abstract
We have discovered that administering anti-ceramide antibody treats and prevents an array of diseases mediated by cytolytic T lymphocyte (CTLs)-induced killing and by damage to endothelial microvasculture, including radiation-induced GI syndrome, Graft vs. Host diseases, inflammatory diseases and autoimmune diseases. We have also discovered new anti-ceramide monoclonal antibodies, that have therapeutic use preferably in humanized form to treat or prevent these diseases.