The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 28, 2021
Filed:
Aug. 12, 2016
The Broad Institute, Inc., Cambridge, MA (US);
Dana-farber Cancer Institute, Inc., Boston, MA (US);
Bayer Pharma Aktiengesellschaft, Berlin, DE;
Luc De Waal, Boston, MA (US);
Matthew Meyerson, Boston, MA (US);
Heidi Greulich, Boston, MA (US);
Monica Schenone, Boston, MA (US);
Alex Burgin, Cambridge, MA (US);
Xiaoyun Wu, Cambridge, MA (US);
Ulrike Sack, Monheim Am Rhein, DE;
The Broad Institute, Inc., Cambridge, MA (US);
Dana-Farber Cancer Institute, Inc., Boston, MA (US);
Bayer Pharma Aktiengesellschaft, Berlin, DE;
Abstract
The present invention features improved methods of identifying patients having cancer (e.g., melanoma, adenocarcinoma, lung, cervical, liver or breast cancer) using biomarkers (e.g., PDE3A, SLFN12) that correlate with drug sensitivity and consequently treating a stratified patient population with an agent of the invention (e.g., DNMDP, zardaverine, and anagrelide).