The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 21, 2021
Filed:
Feb. 20, 2018
Vanderbilt University, Nashville, TN (US);
Daniel C. Liebler, Brentwood, TN (US);
Lisa J. Zimmerman, Franklin, TN (US);
Hyoungjoo Lee, Brentwood, TN (US);
Carlos A. Morales Betanzos, Brentwood, TN (US);
Douglas B. Johnson, Nashville, TN (US);
Vanderbilt University, Nashville, TN (US);
Abstract
The present disclosure relates generally to the analysis of immune checkpoint proteins involved in cancer. In particular, the present disclosure provides material and methods for determining abundance ratios of various immune checkpoint proteins (e.g., PD-1, PD-L1, and PD-L2) present in a biospecimen sample based on quantification of peak area using mass spectrometry analysis. The methods disclosed herein provide an alternative platform for diagnosing and treating cancer, especially in cases limited by ineffective antibody recognition.