The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 21, 2021
Filed:
Jun. 21, 2019
Applicant:
Duke University, Durham, NC (US);
Inventors:
Michael David Lynch, Durham, NC (US);
Zhixia Ye, Raleigh, NC (US);
Assignee:
DUKE UNIVERSITY, Durham, NC (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/12 (2006.01); C12N 9/04 (2006.01); C12P 7/00 (2006.01); C12N 1/20 (2006.01); C12P 7/40 (2006.01); C12N 9/10 (2006.01); C12N 9/02 (2006.01);
U.S. Cl.
CPC ...
C12N 9/1205 (2013.01); C12N 9/0006 (2013.01); C12N 9/0036 (2013.01); C12N 9/0051 (2013.01); C12N 9/1025 (2013.01); C12P 7/40 (2013.01); C12Y 101/01049 (2013.01); C12Y 106/03001 (2013.01); C12Y 108/01004 (2013.01); C12Y 203/03001 (2013.01); C12Y 207/0104 (2013.01);
Abstract
The present disclosure is related to genetically engineered microbial strains and related bioprocesses for the production of pyruvate and related products. Specifically, the use of dynamically controlled synthetic metabolic valves to reduce the activity of enzymes known to contribute to pyruvate synthesis, leads to increased pyruvate production in a two-stage process rather than a decrease in production.