The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 21, 2021
Filed:
Feb. 25, 2020
Applicant:
Northwestern University, Evanston, IL (US);
Inventors:
Richard B. Silverman, Winnetka, IL (US);
Matthew J. Moschitto, Evanston, IL (US);
Assignee:
Northwestern University, Evanston, IL (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 471/08 (2006.01); C07C 233/03 (2006.01); C07C 229/48 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
C07D 471/08 (2013.01); A61K 9/0053 (2013.01); C07C 229/48 (2013.01); C07C 233/03 (2013.01);
Abstract
Disclosed are compound and methods of using the compounds for modulating ornithine aminotransferase (OAT) activity. The disclosed compound are characterized as analogs of 3-amino-4-(propan-2-ylidene)cyclopentane-1-carboxylic acid which may be formulated as therapeutic agents for treating diseases and disorders associated with ornithine aminotransferase (OAT) activity such as hepatocellular carcinoma and other cancers.