The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 21, 2021

Filed:

Mar. 04, 2019
Applicant:

Ecole Polytechnique Federale DE Lausanne (Epfl), Lausanne, CH;

Inventors:

Gregoire Courtine, Lausanne, CH;

Nikolaus Wenger, Pully, CH;

Eduardo Martin Moraud, Pully, CH;

Silvestro Micera, St-sulpice, CH;

Marco Bonizzato, Lausanne, CH;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61N 1/36 (2006.01); A61B 5/11 (2006.01); A61N 1/05 (2006.01); A61B 5/04 (2006.01); A61B 5/0476 (2006.01); A61B 5/0488 (2006.01); A61B 5/00 (2006.01); A61B 5/24 (2021.01); A61B 5/369 (2021.01); A61B 5/389 (2021.01);
U.S. Cl.
CPC ...
A61N 1/36135 (2013.01); A61B 5/112 (2013.01); A61B 5/1121 (2013.01); A61B 5/1127 (2013.01); A61B 5/24 (2021.01); A61B 5/369 (2021.01); A61B 5/389 (2021.01); A61B 5/4836 (2013.01); A61B 5/7282 (2013.01); A61N 1/0551 (2013.01); A61N 1/36003 (2013.01); A61N 1/36067 (2013.01); A61N 1/36103 (2013.01); A61N 1/36139 (2013.01); A61B 2562/0219 (2013.01); A61B 2562/0247 (2013.01);
Abstract

The present invention provides a closed-loop system for real-time control of epidural and/or subdural electrical stimulation comprising: means for applying to a subject neuromodulation with adjustable stimulation parameters, said means being operatively connected with a real-time monitoring component comprising sensors continuously acquiring feedback signals from said subject, said signals being neural signals and/or signals providing features of motion of said subject, said system being operatively connected with a signal processing device receiving said feedback signals and operating real-time automatic control algorithms, said signal processing device being operatively connected with said means and providing said means with new stimulation parameters, with minimum delay. The system of the invention improves consistency of walking in a subject with a neuromotor impairment. A Real Time Automatic Control Algorithm is used, comprising a feedforward component employing a single input-single output model (SISO), or a multiple input-single output (MISO) model.


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