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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11202759 B1

PDFFull Text
Date of Patent:
Dec. 21, 2021

Filed:

Oct. 06, 2011

Injectable, pore-forming hydrogels for materials-based cell therapies

Applicants:

Nathaniel D. Huebsch, Colma, CA (US);

Christopher M. Madl, Vestal, NY (US);

Kangwon Lee, Lexington, MA (US);

Maria M. Xu, Morgantown, WV (US);

David J. Mooney, Sudbury, MA (US);

Inventors:

Nathaniel D. Huebsch, Colma, CA (US);

Christopher M. Madl, Vestal, NY (US);

Kangwon Lee, Lexington, MA (US);

Maria M. Xu, Morgantown, WV (US);

David J. Mooney, Sudbury, MA (US);

Assignee:

President and Fellows of Harvard College, Cambridge, MA (US);

Attorneys:

McCarter & English, LLP

Maria Laccotripe Zacharakis

Maneesh Gulati

Primary Examiner:

Soren Harward

Assistant Examiner:

Paul D Pyla

Int. Cl.
CPC ...
A61L 27/20 (2006.01); A61L 27/22 (2006.01); A61L 27/26 (2006.01); A61L 27/38 (2006.01); A61L 27/54 (2006.01); A61L 27/56 (2006.01); A61L 27/58 (2006.01); A61L 27/52 (2006.01); A61L 27/48 (2006.01); A61K 9/16 (2006.01);
U.S. Cl.
CPC ...
A61K 9/1652 (2013.01); A61L 27/20 (2013.01); A61L 27/26 (2013.01); A61L 27/38 (2013.01); A61L 27/48 (2013.01); A61L 27/52 (2013.01); A61L 27/54 (2013.01); A61L 27/56 (2013.01); A61L 27/58 (2013.01); A61L 2300/414 (2013.01); A61L 2400/06 (2013.01);
Abstract

The invention provides compositions and methods to form pores in situ within hydrogels following hydrogel injection. Pores formed in situ via degradation of sacrificial porogens within the surrounding hydrogel facilitate recruitment or release of cells. Disclosed herein is a material that is not initially porous, but which becomes macroporous over time.

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