The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 14, 2021
Filed:
Dec. 05, 2017
The Administrators of the Tulane Educational Fund, New Orleans, LA (US);
The Scripps Research Institute, La Jolla, CA (US);
The Board of Regents of the University of Texas System, Austin, TX (US);
Zalgen Labs, Llc, Germantown, MD (US);
Luis M. Branco, Germantown, MD (US);
Robert F. Garry, New Orleans, LA (US);
James E. Robinson, New Orleans, LA (US);
Erica O. Saphire, La Jolla, CA (US);
Kathryn M. Hastie, La Jolla, CA (US);
Thomas W. Geisbert, Albany, TX (US);
Other;
Abstract
Disclosed herein are compositions comprising arenavirus monoclonal antibodies, as well as therapeutic, diagnostic, and preventative methods using the novel antibodies. Preventative methods include preparation of vaccines, as well as factors (e.g. small molecules, peptides) that inhibit Old World arenavirus infectivity, including LASV and LCMV. In some embodiments, the antibodies provide pan-arenavirus protection against a number of arenavirus types and strains. Diagnostic and therapeutic antibodies including neutralizing antibodies for the prevention and treatment of infection by LASV and other arenaviruses are also disclosed, as well as new tools and methods for the design, production, and use of arenavirus monoclonal antibodies, including expression in engineered bacterial- and mammalian-based systems.