The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 14, 2021
Filed:
Mar. 25, 2020
Applicant:
Retinal Solutions, Llc, Rochester, MI (US);
Inventors:
Kimberly Drenser, Rochester, MI (US);
Michael T. Trese, Rochester, MI (US);
Antonio Capone, Rochester, MI (US);
Assignee:
RETINAL SOLUTIONS LLC, Rochester, MI (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/515 (2006.01); A61K 38/18 (2006.01); C07K 14/47 (2006.01); C07K 14/475 (2006.01); A61P 27/02 (2006.01); A61K 38/00 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/4705 (2013.01); A61K 38/1891 (2013.01); C07K 14/475 (2013.01); A61K 9/0048 (2013.01); A61K 9/0051 (2013.01); A61K 38/00 (2013.01); A61P 27/02 (2018.01); C07K 14/515 (2013.01);
Abstract
A synthetic truncated norrin protein is provided. The synthetic truncated norrin protein is a −24 residue N-terminus norrin truncate relative to SEQ ID. NO. 1 that retains the cysteine-knot motif and frizzled-4 binding properties and has a mutation in the cysteine-knot motif in at least one position 81-90 of SEQ ID. NO. 1 that interferes with protease cleavage of the resulting protein thereby extending the biological half-life thereof in vivo relative to native norrin.