The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 14, 2021
Filed:
Jun. 29, 2018
Applicant:
Universität Regensburg, Regensburg, DE;
Inventors:
Siavosh Mahboobi, Regensburg, DE;
Herwig Pongratz, Regensburg, DE;
Elisabeth Grünstein, Regensburg, DE;
Assignee:
UNIVERSITÄT REGENSBURG, Regensburg, DE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 471/18 (2006.01); A61K 31/529 (2006.01); A61P 25/28 (2006.01); A61P 35/00 (2006.01); C07D 471/14 (2006.01); C07D 471/22 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07D 471/18 (2013.01); A61P 25/28 (2018.01); A61P 35/00 (2018.01); C07D 471/14 (2013.01); C07D 471/22 (2013.01); A61K 45/06 (2013.01);
Abstract
The present invention relates to small molecule compounds and their use as HDAC inhibitors and their use in the treatment of various diseases, such as cancer. The present invention further relates to methods for improvement of solubility by introducing basic substituents which offer the opportunity to create pharmaceutically acceptable salts. Moreover, it comprises methods of synthesizing the compounds and methods of treatment.