The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 14, 2021
Filed:
Aug. 20, 2020
Applicant:
Cava Healthcare Inc., Vancouver, CA;
Inventors:
Wilfred Jefferies, Surrey, CA;
Reinhard Gabathuler, Montreal, CA;
Raymond Andersen, Vancouver, CA;
Lilian Nohara, Vancouver, CA;
David Williams, Vancouver, CA;
Assignee:
Cava Healthcare Inc., Vancouver, CA;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/045 (2006.01); A61K 31/05 (2006.01); A61N 5/10 (2006.01); A61K 31/12 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/045 (2013.01); A61K 31/05 (2013.01); A61K 31/12 (2013.01); A61K 45/06 (2013.01); A61N 5/10 (2013.01); A61K 2300/00 (2013.01);
Abstract
Provided are methods of using curcuphenol compounds to increase expression of major histocompatibility complex class I (MHC-I) antigen in cells, particularly on the surface of diseased cells such as cancer cells, and thereby increase the immunogenicity of the cells. Also provided are pharmaceutical compositions that comprise curcuphenol compounds and methods of use thereof, for instance, to treat various cancers, alone or in combination with other therapies.