The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 07, 2021

Filed:

Dec. 27, 2018
Applicant:

Synthetic Genomics, Inc., La Jolla, CA (US);

Inventors:

Imad Ajjawi, San Diego, CA (US);

Fedor I. Kuzminov, La Mesa, CA (US);

Randor R. Radakovits, Poway, CA (US);

John H. Verruto, San Diego, CA (US);

Sarah Potts, San Diego, CA (US);

Roberto Spreafico, La Jolla, CA (US);

William F. Lambert, San Diego, CA (US);

Jessica Greiner, San Diego, CA (US);

Assignee:

Synthetic Genomics, Inc., La Jolla, CA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 15/82 (2006.01); A61K 36/02 (2006.01); C12N 15/62 (2006.01); C12N 15/10 (2006.01);
U.S. Cl.
CPC ...
C12N 15/8222 (2013.01); A61K 36/02 (2013.01); C12N 15/8269 (2013.01); C12N 15/102 (2013.01); C12N 15/62 (2013.01); C12N 15/8201 (2013.01); C12N 15/8243 (2013.01);
Abstract

Mutant photosynthetic organisms having reduced chlorophyll and increased photosynthetic efficiency are provided. The mutant strains have mutated or attenuated: chloroplastic SRP54 gene and SGI1 gene; chloroplastic SRP54 gene and SGI2 gene; chloroplastic SRP54 gene, SGI1, and SGI2 genes are disclosed. The mutant photosynthetic organisms exhibit increased productivity with respect to wild-type strains. Also provided are mutant photosynthetic organisms having mutated or attenuated cytosolic SRP54 genes. Provided herein are methods of producing biomass and other products such as lipids using strains having mutations in an SRP54 gene, SGI1, SGI2 genes, a combination of SGI1/SRP54, and a combination of SGI2 and SRP54 genes. Also included are constructs and methods for attenuating or disrupting SRP54, SGI1, and SGI2 genes.


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