The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 07, 2021
Filed:
Apr. 09, 2019
Applicant:
Cornell University, Ithaca, NY (US);
Inventors:
Assignee:
Cornell University, Ithaca, NY (US);
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/18 (2006.01); C07K 16/00 (2006.01); C12N 9/00 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/18 (2013.01); C07K 16/00 (2013.01); C12N 9/93 (2013.01); C12Y 603/02019 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01); C07K 2319/50 (2013.01); C07K 2319/95 (2013.01);
Abstract
The present invention relates to an isolated chimeric molecule comprising a degradation domain including a eukaryotic U-box motif and a targeting domain capable of immunospecifically directing the degradation domain to a substrate where the targeting domain is heterologous to the degradation domain. A linker couples the degradation domain to the targeting domain. Also disclosed are compositions as well as methods of treating a disease, substrate silencing, screening agents for therapeutic efficacy against a disease, and methods of screening for disease biomarkers.