The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 07, 2021
Filed:
Jan. 11, 2019
Applicant:
Enzychem Lifesciences Corporation, Jecheon-si, KR;
Inventors:
Jae Yong Lee, Yongin-si, KR;
Jong Soo Lee, Wonju-si, KR;
Byung Kyu Kang, Jecheon-si, KR;
Byuong Woo Lee, Jecheon-si, KR;
Sang Oh Lee, Daejeon, KR;
Dae Myoung Yun, Wonju-si, KR;
Jae Hun Bang, Daegu, KR;
Ki Young Sohn, Seoul, KR;
Assignee:
ENZYCHEM LIFESCIENCES CORPORATION, Jecheon-si, KR;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 257/02 (2006.01); A61K 49/10 (2006.01);
U.S. Cl.
CPC ...
C07D 257/02 (2013.01); A61K 49/10 (2013.01);
Abstract
Disclosed is a method for producing calcobutrol used as an MRI contrast agent. The method comprises the steps of: obtaining butrol represented by chemical formula 2 in the specification by reacting a gadobutrol represented by chemical formula 1 in the specification and a decomplexing agent; and obtaining a calcobutrol represented by chemical Formula 3 in the specification by reacting butrol with calcium ions.