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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11192859 B1

PDFFull Text
Date of Patent:
Dec. 07, 2021

Filed:

Apr. 18, 2017

Quinoline compounds as modulators of rage activity and uses thereof

Applicants:

New York University, New York, NY (US);

University of Albany, Albany, NY (US);

Inventors:

Ann Marie Schmidt, Franklin Lakes, NJ (US);

Ravichandran Ramasamy, Ardsley, NY (US);

Alexander Shekhtman, Glenmont, NY (US);

Vivek Rai, Allahabad, IN;

Michaele B. Manigrasso, New York, NY (US);

Assignee:

Other;

Attorney:

Hoffmann & Baron, LLP

Primary Examiner:

David K O'Dell

Int. Cl.
CPC ...
C07D 215/14 (2006.01); C07D 215/12 (2006.01); C07D 401/04 (2006.01); A61K 31/4709 (2006.01); C07D 215/52 (2006.01); A61K 31/47 (2006.01); C07D 498/14 (2006.01); A61K 31/5377 (2006.01); A61P 29/00 (2006.01); C07D 401/06 (2006.01); C07D 401/14 (2006.01); C07D 413/14 (2006.01);
U.S. Cl.
CPC ...
C07D 215/14 (2013.01); A61K 31/47 (2013.01); A61K 31/4709 (2013.01); A61K 31/5377 (2013.01); A61P 29/00 (2018.01); C07D 215/12 (2013.01); C07D 215/52 (2013.01); C07D 401/04 (2013.01); C07D 401/06 (2013.01); C07D 401/14 (2013.01); C07D 413/14 (2013.01); C07D 498/14 (2013.01);
Abstract

Quinoline compounds are disclosed that have a formula represented by the following: and wherein Cy, R, R, R, and n are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, diabetes complications, inflammation, and neurodegeneration, obesity, cancer, ischemia/reperfusion injury, cardiovascular disease and other diseases related to RAGE activity.

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