The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 07, 2021

Filed:

Mar. 23, 2020
Applicant:

Illumina, Inc., San Diego, CA (US);

Inventors:

Bradley Kent Drews, Poway, CA (US);

Michael Dai Wang, San Diego, CA (US);

Umberto Ulmanella, San Diego, CA (US);

Stephen Wayne Clark, San Diego, CA (US);

Johanna Lynn Whitacre, San Diego, CA (US);

Steven Scott Phelps, San Diego, CA (US);

Michelle L. Alvarez, San Diego, CA (US);

Michael Adalbert Niziolek, San Diego, CA (US);

Debra Sue Bryan, San Diego, CA (US);

Joshua Augustin Darland, San Diego, CA (US);

Assignee:

Illumina, Inc., San Diego, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
B01L 3/00 (2006.01); G01N 35/10 (2006.01); B01F 15/02 (2006.01); B01F 13/00 (2006.01); B01F 11/00 (2006.01); G01N 35/00 (2006.01); C12Q 1/6869 (2018.01);
U.S. Cl.
CPC ...
B01L 3/502715 (2013.01); B01F 11/0074 (2013.01); B01F 13/0059 (2013.01); B01F 15/0258 (2013.01); B01L 3/50273 (2013.01); B01L 3/502738 (2013.01); G01N 35/1002 (2013.01); G01N 35/1097 (2013.01); B01L 3/52 (2013.01); B01L 2200/027 (2013.01); B01L 2200/14 (2013.01); B01L 2200/16 (2013.01); B01L 2300/0832 (2013.01); B01L 2300/0877 (2013.01); B01L 2300/0883 (2013.01); B01L 2400/04 (2013.01); B01L 2400/0622 (2013.01); B01L 2400/0644 (2013.01); C12Q 1/6869 (2013.01); G01N 2035/00881 (2013.01); G01N 2035/1034 (2013.01);
Abstract

An analysis system may perform operations on an analyte that may be combined with multiple regents prior to being introduced into a flow cell. The instrument may include a volume into which the reagents to be combined with the analyte are aspirated one-by-one. The volume may be formed as a serpentine channel in a valve manifold associated with sippers for aspirating the reagents. The reagents may then be mixed by cycling a pump to move the reagents within the mixing volume or channel. For this, the reagents may be aspirated from a recipient into the volume or channel, ejected back into the recipient, and this process may be performed repeatedly to enhance mixing.


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