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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11191872 B1

PDFFull Text
Date of Patent:
Dec. 07, 2021

Filed:

Apr. 25, 2017

Compositions and methods for grafts modified with a non-thrombogenic and pro-migratory cell-derived extracellular matrix

Applicant:

Yale University, New Haven, CT (US);

Inventors:

Themis Kyriakides, Branford, CT (US);

Nina Kristofik, Wallingford, CT (US);

Assignee:

Yale University, New Haven, CT (US);

Attorneys:

Saul Ewing Arnstein & Lehr LLP

Kathryn Doyle

Primary Examiner:

Scott Long

Assistant Examiner:

Evelyn Y Pyla

Int. Cl.
CPC ...
A61L 27/28 (2006.01); A61L 31/10 (2006.01); A61L 33/12 (2006.01); A61L 29/08 (2006.01); A61L 27/34 (2006.01); A61L 27/36 (2006.01); A61L 27/54 (2006.01); A61L 33/18 (2006.01);
U.S. Cl.
CPC ...
A61L 27/28 (2013.01); A61L 27/34 (2013.01); A61L 27/3633 (2013.01); A61L 27/54 (2013.01); A61L 29/085 (2013.01); A61L 31/10 (2013.01); A61L 33/128 (2013.01); A61L 33/18 (2013.01); A61L 2300/42 (2013.01); A61L 2300/606 (2013.01); A61L 2430/20 (2013.01);
Abstract

The present invention relates to novel compositions and methods for reducing or eliminating the thrombogenicity of a graft by modifying the graft with a cell-derived extracellular matrix lacking thrombospondin-2 (TSP2-null ECM) to render it non-thrombogenic when transplanted to a subject in need thereof. The invention also provides a method for improving the biocompatibility of a medical device or an implant by modifying the medical device or implant with a cell-derived TSP2-null ECM, whereby the medical device or implant is rendered non-thrombogenic and pro-migratory.

Find Patent Forward Citations

Kyriakides, Themis. (2021). Compositions and methods for grafts modified with a non-thrombogenic and pro-migratory cell-derived extracellular matrix (U.S. Patent No. 11191872). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11191872

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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