The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 07, 2021
Filed:
Apr. 13, 2017
Applicant:
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Inventors:
Lili Wang, Phoenixville, PA (US);
James M. Wilson, Philadelphia, PA (US);
Assignee:
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/79 (2006.01); C07H 21/04 (2006.01); A61K 48/00 (2006.01); C12N 15/86 (2006.01); A61P 7/04 (2006.01);
U.S. Cl.
CPC ...
A61K 48/0008 (2013.01); A61K 48/005 (2013.01); A61K 48/0058 (2013.01); A61K 48/0075 (2013.01); A61K 48/0083 (2013.01); C12N 15/86 (2013.01); A61P 7/04 (2018.01); C07H 21/04 (2013.01); C12N 2750/14132 (2013.01); C12N 2750/14143 (2013.01);
Abstract
Compositions for the treatment of hemophilia B are provided. In certain embodiments, the composition is a recombinant adeno-associated virus (rAAV) comprising an AAVrh10 capsid and a vector genome packaged therein, wherein the vector genome comprises an AAV 5' inverted terminal repeat (ITR), a coding sequence for a human Factor IX (F9) having coagulation function operably linked to regulatory elements which direct expression of the human Factor IX in liver cells, and an AAV 3′ ITR.