The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 07, 2021
Filed:
Jun. 07, 2017
Children's Medical Center Corporation, Boston, MA (US);
Dana-farber Cancer Institute, Inc., Boston, MA (US);
Jonathan Abraham, Boston, MA (US);
Stephen Harrison, Boston, MA (US);
Kai Wucherpfennig, Boston, MA (US);
CHILDREN'S MEDICAL CENTER CORPORATION, Boston, MA (US);
DANA-FARBER CANCER INSTITUTE, INC., Boston, MA (US);
Abstract
The invention generally provides compositions and methods of treating or preventing an arenavirus infection, using an agent that inhibits binding of an arenavirus glycoprotein 1 (GP1) polypeptide to transferrin receptor 1 (TfR1). The invention also provides methods of designing or identifying therapeutic agents that bind to or target a GP1 receptor-binding site (RBS) to inhibit arenavirus attachment to a cell, and therapeutic agents identified using the methods.