The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 07, 2021
Filed:
Jul. 16, 2018
President and Fellows of Harvard College, Cambridge, MA (US);
Ohio State Innovation Foundation, Columbus, OH (US);
Daniel E. Kahne, Cambridge, MA (US);
Michael D. Mandler, Cambridge, MA (US);
Vadim Baidin, Cambridge, MA (US);
Natividad Ruiz, Columbus, OH (US);
President and Fellows of Harvard College, Cambridge, MA (US);
The Ohio State University, Columbus, OH (US);
Abstract
This invention features new compositions and methods that are useful in treating a host with a Gram-negative bacterial infection. Combination therapies comprising an aminocoumarin compound and a polymyxin compound are disclosed, including certain combinations that exhibit synergistic effects. Furthermore, aminocoumarin compounds are described having altered inhibition of DNA gyrase in Gram-negative bacteria and/or the ability to target the transport proteins responsible for assembling lipopolysaccharide in the outer membrane of Gram-negative bacteria.