The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 07, 2021

Filed:

Dec. 02, 2019
Applicant:

The Trustees of Columbia University IN the City of New York, New York, NY (US);

Inventors:

Ottavio Arancio, New York, NY (US);

Shixian Deng, White Plains, NY (US);

Donald W. Landry, New York, NY (US);

Jole Fiorito, Floral Park, NY (US);

Rosa Purgatorio, Bari, IT;

Owen Anthony O'Connor, Scarsdale, NY (US);

Jennifer Effie Amengual, Scarsdale, NY (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 209/46 (2006.01); A61K 31/536 (2006.01); C07C 235/64 (2006.01); C07C 235/42 (2006.01); C07C 237/40 (2006.01); C07D 265/22 (2006.01); C07D 265/26 (2006.01); C07D 209/34 (2006.01); C07D 209/38 (2006.01); A61K 31/166 (2006.01); A61K 31/403 (2006.01);
U.S. Cl.
CPC ...
A61K 31/536 (2013.01); A61K 31/166 (2013.01); A61K 31/403 (2013.01); C07C 235/42 (2013.01); C07C 235/64 (2013.01); C07C 237/40 (2013.01); C07D 209/34 (2013.01); C07D 209/38 (2013.01); C07D 209/46 (2013.01); C07D 265/22 (2013.01); C07D 265/26 (2013.01); A61K 2121/00 (2013.01);
Abstract

The invention provides compounds and compositions comprising compounds that modulate histone acyl transferase (HAT). The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a compound that modulates HAT to a subject.


Find Patent Forward Citations

Loading…