The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 30, 2021

Filed:

Oct. 09, 2019
Applicant:

Abs Global, Inc., Deforest, WI (US);

Inventors:

Zheng Xia, Middleton, WI (US);

Yu Zhou, Middleton, WI (US);

John Larsen, Madison, WI (US);

Guocheng Shao, Madison, WI (US);

Shane Peterson, Madison, WI (US);

Marjorie Faust, Waunakee, WI (US);

Assignee:

ABS GLOBAL, INC., Deforest, WI (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
F04B 43/04 (2006.01); B01L 3/00 (2006.01); F04B 43/09 (2006.01); F04B 19/00 (2006.01); G01N 15/14 (2006.01); C12N 5/071 (2010.01); G01N 15/10 (2006.01);
U.S. Cl.
CPC ...
F04B 43/043 (2013.01); B01L 3/50273 (2013.01); B01L 3/502715 (2013.01); B01L 3/502761 (2013.01); B01L 3/502776 (2013.01); C12N 5/0612 (2013.01); F04B 19/006 (2013.01); F04B 43/095 (2013.01); G01N 15/1404 (2013.01); G01N 15/1484 (2013.01); B01L 2200/0636 (2013.01); B01L 2200/0652 (2013.01); B01L 2200/10 (2013.01); B01L 2300/0627 (2013.01); B01L 2300/0816 (2013.01); B01L 2300/0864 (2013.01); B01L 2300/0874 (2013.01); B01L 2300/0887 (2013.01); B01L 2400/0439 (2013.01); B01L 2400/0475 (2013.01); G01N 15/1459 (2013.01); G01N 2015/1006 (2013.01); G01N 2015/1409 (2013.01); Y10T 436/25 (2015.01);
Abstract

A microfluidic chip orients and isolates components in a sample fluid mixture by two-step focusing, where sheath fluids compress the sample fluid mixture in a sample input channel in one direction, such that the sample fluid mixture becomes a narrower stream bounded by the sheath fluids, and by having the sheath fluids compress the sample fluid mixture in a second direction further downstream, such that the components are compressed and oriented in a selected direction to pass through an interrogation chamber in single file formation for identification and separation by various methods. The isolation mechanism utilizes external, stacked piezoelectric actuator assemblies disposed on a microfluidic chip holder, or piezoelectric actuator assemblies on-chip, so that the actuator assemblies are triggered by an electronic signal to actuate jet chambers on either side of the sample input channel, to jet selected components in the sample input channel into one of the output channels.


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